|
Cryptome DVDs are offered by Cryptome. Donate $25 for two DVDs of the Cryptome 12-years collection of 46,000 files from June 1996 to June 2008 (~6.7 GB). Click Paypal or mail check/MO made out to John Young, 251 West 89th Street, New York, NY 10024. The collection includes all files of cryptome.org, jya.com, cartome.org, eyeball-series.org and iraq-kill-maim.org, and 23,000 pages of counter-intelligence dossiers declassified by the US Army Information and Security Command, dating from 1945 to 1985.The DVDs will be sent anywhere worldwide without extra cost. |
27 June 2008
[Federal Register: June 27, 2008 (Volume 73, Number 125)]
[Notices]
[Page 36501]
From the Federal Register Online via GPO Access [wais.access.gpo.gov]
[DOCID:fr27jn08-41]
=======================================================================
-----------------------------------------------------------------------
ENVIRONMENTAL PROTECTION AGENCY
[FRL-8685-8]
Concepts, Methods, and Data Sources for Cumulative Health Risk
Assessment of Multiple Chemicals, Exposures, and Effects: A Resource
Document
AGENCY: Environmental Protection Agency (U.S. EPA).
ACTION: Notice of Availability.
-----------------------------------------------------------------------
SUMMARY: The U.S. EPA announces the availability of a final document
entitled, ``Concepts, Methods, and Data Sources for Cumulative Health
Risk Assessment of Multiple Chemicals, Exposures, and Effects: A
Resource Document'' (EPA/600/R-06/013F), which was prepared by the
National Center for Environmental Assessment (NCEA) within the U.S.
EPA's Office of Research and Development (ORD).
This document represents a collaborative effort between the U.S.
EPA and the U.S. Department of Energy (U.S. DOE) that is designed to
serve as an interim resource between U.S. EPA's 2003 ``Framework for
Cumulative Risk Assessment'' (EPA/630/P-02/001F) and future documents
on approaches and guidance to cumulative risk assessment. The document
provides concepts, methods, and data sources for consideration and
possible use in the conduct of a cumulative risk assessment.
Specifically, the document focuses on two areas: (1) Initiating factors
for a cumulative risk assessment, with procedures for data collection
and organization, and (2) technical approaches for assessing human
health risks associated with a subset of cumulative risk issues (i.e.,
multiple chemicals, exposures, and effects). Overall, this document
demonstrates the feasibility of including combinations of chemicals,
exposures, effects and their interactions into a cumulative risk
assessment and is meant to assist with the conduct of multi-chemical,
population-focused assessments.
This document has undergone review within the U.S. EPA, independent
external peer review by a panel of scientific experts, and it has also
benefited from a 45-day public comment period. However, it has not
undergone the scrutiny required of a guidance document and, thus, does
not represent U.S. EPA policy.
DATES: This document will be available on or about June 26, 2008.
ADDRESSES: The document will be available electronically through the
National Center for Environmental Assessment (NCEA) Web site at http://
www.epa.gov/ncea. A limited number of paper copies will be available
from the U.S. EPA's National Service Center for Environmental
Publications (NSCEP); P.O. Box 42419; Cincinnati, OH 45242; (800) 490-
9198 (telephone); (301) 604-3408 (facsimile); nscep@bps-lmit.com.
Please provide your name, your mailing address, the title and the EPA
number of the requested publication.
FOR FURTHER INFORMATION CONTACT: Linda K. Teuschler, Project Leader,
NCEA-Cin; 26 W. Martin Luther King Dr. (A-G20); Cincinnati, OH 45268;
(513) 569-7573 (telephone); (513) 487-2539 (fax);
teuschler.linda@epa.gov.
SUPPLEMENTARY INFORMATION: The U.S. EPA's 2003 ``Framework for
Cumulative Risk Assessment'' and earlier reports from the 1990s on the
initial planning and scoping phase needed to conduct a cumulative risk
assessment laid a broad foundation for continued development of
cumulative risk approaches. The 2003 Framework describes some basic
considerations for conducting a cumulative risk assessment and outlines
four areas of population vulnerability: Susceptibility or sensitivity,
differential exposure (e.g., living in close proximity to pollutant
sources), differential preparedness (e.g., lack of disease
immunizations), and differential ability to recover from exposures.
Since 1986, U.S. EPA technical and guidance documents have been
published that address chemical mixture risk assessments which can be
used for cumulative risk assessment, but additional research has been
needed to address chemical mixtures in combination with multiple
exposures and effects.
In February 2001, the U.S. EPA began collaborating with the U.S.
DOE in an effort to collect data and develop methods for use in
cumulative risk assessments. This present document, ``Concepts,
Methods, and Data Sources for Cumulative Health Risk Assessment of
Multiple Chemicals, Exposures, and Effects: A Resource Document,'' is
the final product of that effort. It further develops the knowledge
base for conducting cumulative risk assessments by providing details
regarding the evaluation of the human health and population aspects of
cumulative risk assessment and by introducing practical ideas for
addressing multiple chemicals, exposures, and effects.
The U.S. EPA released the external review draft in March 2006 for a
45-day public comment period (see 71 FR 16306-16307, March 31, 2006;
Docket ID No. EPA-HQ-ORD-2006-0223). The draft received an independent
peer review conducted by the Eastern Research Group under U.S. EPA
contract number 68-C-02-060. The peer review included a two-day
workshop in May 2006 and featured an external panel of scientific
reviewers (see 71 FR 26365-26366, May 4, 2006; Docket ID No. EPA-HQ-
ORD-2006-0223).
Dated: June 20, 2008.
Rebecca Clark,
Acting Director, National Center for Environmental Assessment.
[FR Doc. E8-14623 Filed 6-26-08; 8:45 am]
BILLING CODE 6560-50-P