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9 September 1998
Source: http://www.ilpi.com/msds/vx.html
Thanks to L.

MATERIAL SAFETY DATA SHEET

LETHAL NERVE AGENT (VX)

Thanks to Edgewood Research Development and Engineering Center for this MSDS sample

DATE: 14 September 1988
REVISED: 28 February 1996

MANUFACTURER'S ADDRESS:

U.S. ARMY CHEMICAL BIOLOGICAL DEFENSE COMMAND
EDGEWOOD RESEARCH DEVELOPMENT, AND ENGINEERING CENTER (ERDEC)
ATTN: SCBRD-ODR-S
ABERDEEN PROVING GROUND, MD 20101-5423

Emergency telephone #' s: 0700-1630 EST: 410-671-4411/4414
After: 1630 EST: 410- 278-5201, Ask for Staff Duty Officer

CAS REGISTRY NUMBERS: 50782-69-9, 51848-47-6, 53800-40-1, 70938-84-0

CHEMICAL NAME:

• O-ethyl-S-(2-iisopropylaminoethyl) methyl phosphonothiolate
  

TRADE NAME AND SYNONYMS:

• Phosphonothioic acid, methyl-, S-(2-bis(1-methylethylamino)ethyl) 0-ethyl ester
  O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothiolate
  S-2-Diisopropylaminoethyl O-ethyl methylphosphonothioate
  S-2((2-Diisopropylamino)ethyl) O-ethyl methylphosphonothiolate
  O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothioate
  O-ethyl S-(2-diisopropylaminoethyl) methylthiolphosphonoate
  S-(2-diisopropylaminoethyl) o-ethyl methyl phosphonothiolate
  Ethyl-S-dimethylaminoethyl methylphosphonothiolate
  VX
  EA 1701
  TX60

CHEMICAL FAMILY: Sulfonated organophosphorous compound

FORMULA/CHEMICAL STRUCTURE:
C11H26NO2PS

NFPA 704 HAZARD SIGNAL:

Health - 4
Flammability - 1
Reactivity - 1
Special - 0

SECTION II - HAZARDOUS INGREDIENTS

SECTION III - PHYSICAL DATA

BOILING POINT : 298 C (568 F)

VAPOR PRESSURE (mm Hg): 0.0007 @ 20 C

VAPOR DENSITY (AIR=1): 9.2

FREEZING/MELTING POINT : Below -51 C

LIQUID DENSITY (g/cc): 1.0083 @ 20 C

PERCENTAGE VOLATILE BY VOLUME: 10.5 mg/m3 @ 25 C

SOLUBILITY: Slightly soluble in water at room temperature. Soluble in organic solvents.

APPEARANCE AND ODOR: Colorless to straw colored liquid & odorless, similar in appearance to motor oil.

SECTION IV - FIRE AND EXPLOSION DATA

FLASHPOINT: 159 C (McCutchan - Young)

FLAMMABILITY LIMITS (% by volume): Not Available

LOWER EXPLOSIVE LIMIT: Not Applicable

UPPER EXPLOSIVE LIMIT: Not Applicable

EXTINGUISHING MEDIA: Water mist, fog, foam, CO2. Avoid using extinguishing methods that will cause splashing or spreading of the VX.

SPECIAL FIRE FIGHTING PROCEDURES: All persons not engaged in extinguishing the fire should be immediately evacuated from the area. Fires involving VX should be contained to prevent contamination to uncontrolled areas. When responding to a fire alarm in buildings or areas containing VX , fire fighting personnel should wear full firefighter protective clothing (without TAP clothing) during chemical agent firefighting and fire rescue operations. Respiratory protection is required. Positive pressure, full face piece, NIOSH-approved self-contained breathing apparatus (SCBA) will be worn where there is danger of oxygen deficiency and when directed by the fire chief of chemical accident/incident (CAI) operations officer. In cases where firefighters are responding to a chemical accident/incident for rescue/reconnaissance purposes they will wear appropriate levels of protective clothing (See Section VIII).

Do not breathe fumes. Skin contact with nerve agents must be avoided at all times. Although the fire may destroy most of the agent, care must still be taken to assure the agent or contaminated liquids do not further contaminate other areas or sewers. Contact with liquid VX or vapors can be fatal.

UNUSUAL FIRE AND EXPLOSION HAZARDS: None known.

SECTION V - HEALTH HAZARD DATA

AIRBORNE EXPOSURE LIMITS (AEL): The permissible airborne exposure concentration for VX for an 8-hour workday of a 40-hour work week is an 8-hour time weighted average (TWA) of 0.00001 mg/m3. This value can be found in "AR 40-8, Occupational Health Guidelines for the Evaluation and Control of Occupational Exposure to Nerve Agents GA, GB, GD, and VX." To date, however, the Occupational Safety and Health Administration (OSHA) has not promulgated a permissible exposure concentration for VX.

VX is not listed by the International Agency for Research on Cancer (IARC), American Conference of Governmental Industrial Hygienists (ACGIH), Occupational Safety and Health Administration (OSHA), or National Toxicology Program (NTP) as a carcinogen.

EFFECTS OF OVEREXPOSURE: VX is a lethal cholinesterase inhibitor. Doses which are potentially life-threatening may be only slightly larger than those producing least effects. Death usually occurs within 15 minutes after absorption of a fatal dosage.

VX

Route ocular inhalation inhalation (15 1/min) inhalation (15 1/min) percutaneous

Form vapor vapor vapor vapor liquid

Effect miosis runny nose severe incapacitation death death

Type ECt50 ECt50 ICt50 LCt50 LD50

Dosage < 0.09 mg-min/m3 < 0.09 mg-min/m3 25 mg-min/m3 30 mg-min/m3 10 mg/70 kg man

Effective dosages for vapor are estimated for exposure durations of 2-10 minutes.

Symptoms of overexposure may occur within minutes or hours, depending upon the dose. They include: miosis (constriction of pupils) and visual effects, headaches and pressure sensation, runny nose and nasal congestion, salivation, tightness in the chest, nausea, vomiting, giddiness, anxiety, difficulty in thinking, difficulty sleeping, nightmares, muscle twitches, tremors, weakness, abdominal cramps, diarrhea, involuntary urination and defecation. With severe exposure symptoms progress to convulsions and respiratory failure.

EMERGENCY AND FIRST AID PROCEDURES:

INHALATION: Hold breath until respiratory protective mask is donned. If severe signs of agent exposure appear (chest tightens, pupil constriction, incoordination, etc.), immediately administer, in rapid succession, all three Nerve Agent Antidote Kit(s), Mark I injectors (or atropine if directed by physician). Injections using the Mark I kit injectors may be repeated at 5 to 20 minute intervals if signs and symptoms are progressing until three series of injections have been administered. No more injections will be given unless directed by medical personnel. In addition, a record will be maintained of all injections given. If breathing has stopped, give artificial respiration. Mouth-to-mouth resuscitation should be used when approved mask-bag or oxygen delivery systems are not available. Do not use mouth-to-mouth resuscitation when facial contamination exists. If breathing is difficult, administer oxygen. Seek medical attention IMMEDIATELY.

EYE CONTACT: IMMEDIATELY flush eyes with water for 10-15 minutes, then don respiratory protective mask. Although miosis (pinpointing of the pupils) may be an early sign of agent exposure, an injection will not be administered when miosis is the only sign present. Instead, the individual will be taken IMMEDIATELY to a medical treatment facility for observation.

SKIN CONTACT: Don respiratory protective mask and remove contaminated clothing. Immediately wash contaminated skin with copious amounts of soap and water, 10% sodium carbonate solution, or 5% liquid household bleach. Rinse well with water to remove excess decontaminant. Administer nerve agent antidote kit, Mark I, only if local sweating and muscular twitching symptoms are observed. Seek medical attention IMMEDIATELY .

INGESTION: Do not induce vomiting. First symptoms are likely to be gastrointestinal. IMMEDIATELY administer Nerve Agent Antidote Kit, Mark I. Seek medical attention IMMEDIATELY .

SECTION VI - REACTIVITY DATA

STABILITY: Relatively stable at room temperature. Unstabilized VX of 95% purity decomposes at a rate of 5% a month at 71 C.

INCOMPATIBILITY: Negligible on brass, steel, aluminum.

HAZARDOUS DECOMPOSITION PRODUCTS: During a basic hydrolysis of VX up to 10% of the agent is converted to diisopropylaminoethyl methylphosphonothioic acid (EA2192). Based on the concentration of EA2192 expected to be formed during hydrolysis and its toxicity (1.4 mg/kg dermal in rabbit at 24 hours in a 10/90 wt.% ethanol/water solution), a Class B poison would result. The large scale decon procedure, which uses both HTH and NaOH, destroys VX by oxidation and hydrolysis. Typically the large scale product contains 0.2 - 0.4 wt.% EA2192 at 24 hours. At pH 12, the EA2192 in the large scale product has a half-life of about 14 days. Thus, the 90-day holding period at pH 12 results in about a 64-fold reduction of EA2192 (six half-lives). This holding period is sufficient to reduce the toxicity of the product below that of a Class B poison. Other less toxic products are ethyl methylphosphonic acid, methylphosphinic acid, diisopropyaminoethyl mercaptan, diethyl methylphosphonate, and ethanol. The small scale decontamination procedure uses sufficient HTH to oxidize all VX thus no EA2192 is formed.

HAZARDOUS POLYMERIZATION: Does not occur.

SECTION VII - SPILL, LEAK, AND DISPOSAL PROCEDURES

STEPS TO BE TAKEN IN CASE MATERIAL IS RELEASED OR SPILLED: If leaks or spills occur, only personnel in full protective clothing (See Section VIII ) will remain in area. In case of personnel contamination see (Section V) for emergency and first aid instructions.

RECOMMENDED FIELD PROCEDURES (For Quantities greater than 50 grams): (NOTE: These procedures can only be used with the approval of the Risk Manager or qualified safety personnel). Spills must be contained by covering with vermiculite, diatomaceous earth, clay or fine sand. An alcoholic HTH mixture is prepared by adding 100 milliliters of denatured ethanol to a 900-milliliter slurry of 10% HTH in water. This mixture should be made just before use since the HTH can react with the ethanol. Fourteen grams of alcoholic HTH solution are used for each gram of VX. Agitate the decontamination mixture as the VX is added. Continue the agitation for a minimum of one hour. This reaction is reasonablely exothermic and evolves substantial off gassing. The evolved reaction gases should be routed through a decontaminate filled scrubber before release through filtration systems. After completion of the one hour minimum agitation, 10% sodium hydroxide is added in a quantity equal to that necessary to assure that a pH of 12.5 is maintained for a period not less than 24 hours. Hold the material at a pH between 10 and 12 for a period not less than 90 days to ensure that a hazardous intermediate material is not formed (See Section VI). Scoop up all material and clothing and place in a DOT approved container. Cover the contents with decontaminating solution as above. After sealing, the exterior of the container will be decontaminated and labeled according to EPA and DOT regulations. All leaking containers will be over packed with vermiculite placed between the interior and exterior containers. Decontaminate and label according to EPA and DOT regulations. Dispose of the material according to waste disposal methods provided below. Dispose of decontaminate according to Federal, State, and local regulations. Conduct general area monitoring to confirm that the atmospheric concentrations do not exceed the airborne exposure limits (See Sections II and VIII).

If the alcoholic HTH mixture is not available then the following decontaminants may be used instead and are listed in the order of preference: Decontaminating Agent D2 (DS2), Supertropical Bleach Slurry (STB), and Sodium Hypochlorite.

RECOMMENDED LABORATORY PROCEDURES (For Quantities less than 50 grams): If the active chlorine of the Calcium Hypochlorite (HTH) is at least 55%, then 80 grams of a 10% slurry are required for each gram of VX. Proportionally more HTH is required if the chlorine activity of the HTH is lower than 55%. The mixture is agitated as the VX is added and the agitation is maintained for a minimum of one hour. If phasing of the VX/decon solution continues after 5 minutes, an amount of denatured ethanol equal to a 10 wt.% of the total agent/decon will be added to help miscibility. Scoop up all material and clothing and place in a DOT approved container. Cover the contents with decontaminating solution as above. After sealing, the exterior of the container will be decontaminated and labeled according to EPA and DOT regulations. All leaking containers will be over packed with vermiculite placed between the interior and exteriorcontainers. Decontaminate and label according to EPA and DOT regulations. Dispose of the material according to waste disposal methods provided below. Dispose of decontaminate according to Federal, State, and local regulations. Conduct general area monitoring to confirm that the atmospheric concentrations do not exceed the airborne exposure limits (See Sections II and VIII).

NOTE: ETHANOL SHOULD BE REDUCED TO PREVENT THE FORMATION OF A HAZARDOUS WASTE. Upon completion of the one hour agitation the decon mixture will be adjusted to a pH between 10 and 11. Conduct general area monitoring to confirm that the atmospheric concentrations do not exceed the airborne exposure limits (See Sections II and VIII).

WASTE DISPOSAL METHOD: Open pit burning or burying of VX or items containing or contaminated with VX in any quantity is prohibited. The detoxified VX (using procedures above) can be thermally destroyed by in a EPA approved incinerator in accordance with appropriate provisions of Federal, State and local Resource Conservation and Recovery Act (RCRA) regulations.

NOTE: Some states define decontaminated surety material as a RCRA Hazardous Waste.

SECTION VIII - SPECIAL PROTECTION INFORMATION

RESPIRATORY PROTECTION:

CONCENTRATION	RESPIRATORY PROTECTIVE EQUIPMENT
< 0.00001 mg/m3	A full face piece, chemical canister, air-purifying protective mask will be on hand for escape. (The M9-, M17-, or M40-series masks are acceptable for this purpose. Other masks certified as equivalent may be used).
>0.00001 or = 0.02 mg/m3	A NIOSH/MSHA approved pressure demand full face piece SCBA or supplied air respirators with escape air cylinder may be used. Alternatively, a full face piece, chemical canister air-purifying protective mask is acceptable for this purpose (See DA PAM 385-61for determination of appropriate level)
>0.02 mg/m3 or unknown	NIOSH/MSHA approved pressure demand full f ace piece SCBA suitable for use in high agent concentrations with protective ensemble (See DA PAM 385-61 for examples).

VENTILATION:

Local exhaust: Mandatory. Must be filtered or scrubbed to limit exit concentration to <0.00001 mg/m3. Air emissions will meet local, state and federal regulations.

Special: Chemical laboratory hoods will have an average inward face velocity of 100 linear feet per minute (lfpm) +/- 10% with the velocity at any point not deviating from the average face velocity by more than 20%. Existing laboratory hoods will have an inward face velocity of 150 lfpm +/- 20%. Laboratory hoods will be located such that cross-drafts do not exceed 20% of the inward face velocity. A visual performance test using smoke-producing devices will be performed in assessing the ability of the hood to contain agent VX.

Other: Recirculation or exhaust air from chemical areas is prohibited. No connection between chemical areas and other areas through ventilation system is permitted. Emergency backup power is necessary. Hoods should be tested at least semiannually or after modification or maintenance operations. Operations should be performed 20 centimeters inside hood face.

PROTECTIVE GLOVES: Butyl Rubber Glove M3 and M4 Norton, Chemical Protective Glove Set

EYE PROTECTION: At a minimum chemical goggles will be worn. For splash hazards use goggles and face shield.

OTHER PROTECTIVE EQUIPMENT: For laboratory operations, wear lab coats, gloves and have mask readily accessible. In addition, daily clean smocks, foot covers, and head covers will be required when handling contaminated lab animals.

MONITORING: Available monitoring equipment for agent VX is the M8/M9 detector paper, detector ticket, M256/M256A1 kits, bubbler, Depot Area Air Monitoring System (DAMMS), Automated Continuous Air Monitoring System (ACAMS), Real-Time Monitor (RTM), Demilitarization Chemical Agent Concentrator (DCAC), M8/M43, M8A1/M43A1, CAM-M1, Hydrogen Flame Photometric Emission Detector (HYFED), the Miniature Chemical Agent Monitor (MINICAM), and the Real Time Analytical Platform (RTAP).

Real-time, low-level monitors (with alarm) are required for VX operations. In their absence, an Immediately Dangerous to Life and Health (IDLH) atmosphere must be presumed. Laboratory operations conducted in appropriately maintained and alarmed engineering controls require only periodic low-level monitoring.

SECTION IX - SPECIAL PRECAUTIONS

PRECAUTIONS TO BE TAKEN IN HANDLING AND STORING: When handling agents the buddy system will be incorporated. No smoking, eating, and drinking in areas containing chemicals is permitted. Containers should be periodically inspected for leaks (either visually or by a detector kit). Stringent control over all personnel practices must be exercised. Decontamination equipment will be conveniently located. Exits must be designed to permit rapid evacuation.Chemical showers, eyewash stations and personal cleanliness facilities must be provided. Wash hands before meals, each worker will shower thoroughly with special attention given to hair, face, neck, and hands, using plenty of soap and water before leaving at the end of the workday.

OTHER PRECAUTIONS: VX must be double contained in liquid and vapor tight containers when in storage or outside a ventilation hood.

For additional information see "AR 385-61, The Army Toxic Chemical Agent Safety Program," "DA PAM 385-61, Toxic Chemical Agent Safety Standards," and "AR 40-8, Occupational Health Guidelines for the Evaluation and Control of Occupational Exposure to Nerve Agents GA, GB, GD, and VX."

SECTION X - TRANSPORTATION DATA

PROPER SHIPPING NAME: Poisonous liquids, n.o.s.

DOT HAZARD CLASS: 6.1 Packing Group I, Zone A

DOT LABEL: Poison

DOT MARKING: Poisonous liquids, n.o.s. (O-ethyl S-(2-diisopropylaminoethyl)methyl phosphonothiolate) UN 2810, Inhalation Hazard

DOT PLACARD: Poison

EMERGENCY ACCIDENT PRECAUTIONS AND PROCEDURES: See Sections IV, VII and VIII.

PRECAUTIONS TO BE TAKEN IN TRANSPORTATION: Motor vehicles will be placarded, regardless of quantity. Drivers will be given full information regarding shipment and conditions in case of an emergency. AR 50-6 deals specifically with the shipment of chemical agents. Shipments of agent will be escorted in accordance with AR 740-32.

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This page was last updated July 11, 1998